密苏里州立大学（英语：Missouri State University，缩写为 MSU 或 MO State），前身为西南密苏里州立大学（Southwest Missouri State University），美国公立大学，位于密苏里州春田市，创立于1905年。它是密苏里州第二大的大学，根据2014年官方统计，共有22,385名学生登记在学。

Missouri State University (MSU or MO State), formerly Southwest Missouri State University, is a public university located in Springfield, Missouri, United States and was founded in 1905. It is the state's second largest university, with an official enrollment of 22,385 in the fall 2014 semester. In 2011, students represented 50 states, the District of Columbia, the Virgin Islands, and 83 countries. The Springfield campus is one of two degree-granting institutions within the Missouri State University System, the other being a two-year campus in West Plains, Missouri. A bachelor of science in business from MSU is offered at the Missouri State University Branch Campus Dalian in the People's *****************. In addition to its main campus, MSU maintains a fruit research station in Mountain Grove and the Department of Defense and Strategic Studies program housed in Fairfax, Virginia. The school is classified by the Carnegie Classification of Institutions of Higher Education as one of six master's colleges and universities in Missouri. In the 2014 U.S. News and World Report the school was ranked 68th in the category Midwestern regional universities.