Silifke (Greek: Σελεύκεια, Seleukeia, Latin:Seleucia ad Calycadnum) is a town and district in south-central Mersin Province, Turkey, 80 km (50 mi) west of the city of Mersin, on the west end of Çukurova.

Silifke is near the Mediterranean coast, on the banks of the Göksu River, which flows from the nearby Taurus Mountains, surrounded by attractive countryside along the river banks.