It is a significant problem around the world.

这是全球范围内的严重问题。

And when they do, it can create some significant problems.

当它们死的时候，就会产生一些严重的问题。

Alvarez said she knew her building had significant maintenance problems.

阿尔瓦雷斯表示，她知道她居住的大楼存在严重的维修问题。

It is a very significant city but with a very significant problem.

这是一座非常重要的城市，但也有一个非常严重的问题。

Alcoholism and alcohol-related deaths have almost always been a significant problem in Russia.

酗酒和与酒精有关的死亡几乎一直是俄罗斯的一个严重问题。

Alright, let's think of a more significant problem that maybe you created now.

好的，让我们想一下你现在可能造成了什么更加重大的问题吧。

One of the most significant problems plaguing the team is the pace of domestic competition.

困扰球队的最重要问题之一是国内比赛的节奏。

These unhealthy traits can cause significant problems and limitations in relationships, social activities, work, school, and other situations.

这些不健康的性格会在人际关系、社会活动、工作、学校和其他场合带来严重的问题和局限性。

What makes these traits a true personality disorder is that they take over people's lives and cause significant problems.

这些特质成为真正的人格障碍的原因，是他们主导别人的生活并且造成严重的麻烦。

What makes these trait a true personality disorder is that they take over people's lives and cause significant problems.

使得这些特质成为真正的人格障碍的是他们主导别人的生活 并且造成重大的麻烦。

Or in a professional context, when your mistake has resulted in a significant problem for your customer or your company.

或者是在职业场合，当你的错误对顾客或者是公司造成了严重问题的时候。

It is a significant problem around the  world, there's about one billion people.

这是全世界的一个重大问题，大约有 10 亿人。

In addition to posing a significant health and environmental problem, this is a source of great embarrassment for all of us.

除了造成严重的健康和环境问题之外，也让我们处在尴尬的境地。

Air pollution has become one of the most significant health problems of our time.

【time】空气污染成了我们这个时代最重大的健康问题。

This possibility presents a significant problem, the same one Andrew Steele discovered in the late 1990s.

这种可能性提出了一个重大问题，与 Andrew Steele 在 1990 年代后期发现的问题相同。

It is a significant problem around the  world, there's about 1 billion people.

这是全世界的一个重大问题，大约有 10 亿人。

In our society, about 10% of the populace - that's 30 million people - have significant hearing problems.

在我们的社会中，大约 10% 的人口（即 3000 万人）存在严重的听力问题。

In conclusion, climate change is a significant problem that has a damaging effect on the planet and its inhabitants.

总之， 气候变化是一个对地球及其居民具有破坏性影响的重大问题。

Lead is an extremely toxic heavy metal and studies have linked exposure to it to significant health and developmental problems, especially for kids.

铅是一种剧毒的重金属，研究表明，接触铅会导致严重的健康和发育问题，尤其是对儿童而言。

A significant problem. Maybe not a huge problem, but not a tiny problem either. Big enough to have an effect to be important.

一个重要的问题。也许不是一个巨大的问题，但也不是一个微小的问题。大到足以产生影响，成为重要问题。