Sideroblastic anemia can be congenital or acquired.

铁粒幼细胞性贫血可以是先天性或后天获得的。

Clinically, patients with sideroblastic anemia present very similarly to patient with hemochromatosis.

临床上，铁粒幼细胞贫血患者与血色素沉着病患者表现非常相似。

Now with sideroblastic anemia, there's defective protoporphyrin synthesis, which results in impaired incorporation of iron to form heme.

在铁粒幼细胞性贫血中，原卟啉合成存在缺陷，导致铁结合形成血红素的能力受损。

The acquired causes of sideroblastic anemia include excessive alcohol use, pyridoxine or vitamin B6 deficiency and lead poisoning.

获得性铁粒幼细胞性贫血的原因包括过量饮酒、吡哆醇（维生素B6）缺乏，以及铅中毒。

A diagnosis of sideroblastic anemia can be reached with a combination of both clinical judgment and laboratory findings.

铁粒幼细胞性贫血的诊断需结合临床判断与实验室检查结果。

Treatment of sideroblastic anemia involves removal of toxins if there are any, and administering pyridoxine, thiamine, and folic acid.

铁粒幼细胞贫血的治疗包括去除可能存在的毒素，服用吡哆醇、硫胺素和叶酸。

In order to better understand sideroblastic anemia, we need to first take a look at hemoglobin, the main protein within RBCs that's responsible for carrying oxygen.

为了更好地了解铁粒幼细胞性贫血，我们首先要了解血红蛋白，它是红细胞中负责运输氧气的主要蛋白质。

So sideroblastic anemia is a type of blood disorder where there's a buildup of iron in the RBCs in the body, causing them to be immature and dysfunctional.

铁粒幼细胞性贫血，是一类由于红细胞中过量铁元素堆积而导致的红细胞不成熟及功能异常的血液疾病。

These causes of sideroblastic anemia stops the iron from being incorporated to form heme, which allows the iron to accumulate in the mitochondria, resulting in Pappenheimer bodies seen on blood film.

这些导致铁粒幼细胞性贫血的原因阻止了铁结合形成血红素的过程，使得铁在线粒体内积累，从而导致在血涂片上可见帕彭海默氏小体。

All right, as a quick recap, sideroblastic anemia happens when there is either a congenital abnormality or an acquired cause, like vitamin B6 deficiency, excessive alcohol use or lead poisoning, which leads to an inability to incorporate iron to form heme.

好，快速回顾一下：铁粒幼细胞性贫血可由先天性缺陷或获得性原因导致，如维生素B6的缺乏、过度饮酒或铅中毒，均会导致机体无法结合铁形成血红素。