Taita-Taveta has an alarming rate of sickle cell disease.

Taita-Taveta已对该疾病的出现亮起警示灯。

Sickle cell disease is caused by defective hemoglobin, which is the oxygen-carrying protein in red blood cells.

镰状细胞病是由有缺陷的血红蛋白引起，后者是红细胞中的携氧蛋白。

To treat sickle cell disease, researchers used CRISPR to make the body produce the fetal form of hemoglobin.

为了治疗镰状细胞病，研究人员使用 CRISPR 使身体产生胎儿形式的血红蛋白。

Life in Nigeria had already shown him that sickle cell disease was fated by birth, not by upbringing.

尼日利亚的生活已经告诉他，镰状细胞病是先天的，而不是后天发生。

" the United States … has really taken bold leadership in bringing sickle cell disease to the forefront, " said Admiral Giroir.

" 美国真正勇敢地带头把镰状细胞病放在最优先处置的地位。" 吉罗伊尔上将表示。

To counteract the anemia of sickle cell disease, the bone marrow makes increased numbers of reticulocytes, which are immature red blood cells.

为代偿镰状细胞贫血，骨髓造血活跃并产生大量网织红细胞，即尚未完全成熟的红细胞。

In sickle cell, disease protein crystals formed inside the cells changing them to a crescent-shape, clogging vessels and causing pain and organ damage.

在镰状细胞中，细胞内形成的病变蛋白质晶体会使细胞变成新月形，会堵塞血管，从而造成疼痛和器官损伤。

Other potential causes of renal papillary necrosis are chronic use of analgesics, like aspirin, as well as diabetes mellitus, sickle cell disease, and pyelonephritis.

其他肾乳头坏死的潜在原因是长期使用止痛药，如阿司匹林、糖尿病、镰状细胞疾病以及肾盂肾炎。

Sickle cell disease, where blood cells are sickle-shaped due to a structurally abnormal hemoglobin protein that can cause tissue ischemia, has been linked to FSGS.

血细胞因血红蛋白结构异常而整体呈现镰刀形，可导致组织缺血，与FSGS有关。

This phenomenon is called heterozygote advantage; and its unfortunate consequence is a high rate of sickle cell disease in people from those parts of the world.

该现象被称为杂合子优势；其伴随的不幸后果是这些地区有高比例的镰状细胞病患者。

To prevent complications from an existing blood or bleeding disorder, such as sickle cell disease, thalassemia, or anaemia caused by kidney disease, haemophilia, or von Willebrand disease.

预防现有血液或出血性疾病的并发症，如镰状细胞病、地中海贫血或由肾脏疾病、血友病或血管性血友病引起的贫血。

These patients who had sickle cell disease, now when you look at their blood counts and their blood smears, it looks like they don't have it anymore.

这些患有镰状细胞病的患者，现在当你看他们的血细胞计数和血涂片时，看起来他们体内不再有镰状细胞了。

CRISPR, amazingly, has already cured people of devastating disorders like sickle cell disease, and it's created rice plants that are resistant to both diseases and drought.

令人惊奇的是， CRISPR 已经治愈了人们的镰状细胞病等毁灭性疾病，并且它培育出了能够抵抗疾病和干旱的水稻植物。

One of the most recent advances is the ability to treat sickle cell disease, a blood disorder which is caused by a mutation in a single gene.

最近的一项进展是能够治疗镰状细胞病，这是一种由单个基因突变引起的血液疾病。

As a quick recap: sickle cell disease is an autosomal recessive genetic disease where the beta-globin subunit of hemoglobin is misshapen, which causes red blood cells to sickle when deoxygenated.

好！简要回顾一下：镰状细胞病，是常染色体隐性遗传病，其中血红蛋白的β-珠蛋白发生突变，脱氧情况下会导致红细胞镰变。

It helped patients with two inherited blood diseases — beta-thalassemia, where low levels of an oxygen-carrying protein called hemoglobin lead to weakness and exhaustion, and sickle cell disease, caused by a defective form of the same protein.

它帮助了两种遗传性血液病的患者——地中海贫血症和镰状细胞病，前者是一种叫做血红蛋白的携氧蛋白含量低，导致虚弱和疲惫，后者是由同一蛋白的缺陷形式引起的。