Seyne is a commune in the Alpes-de-Haute-Provence department, and in the region of Provence-Alpes-Côte d'Azur, in southeastern France. It is around 30 km north of Digne.

The official name of the municipality, as listed by the INSEE official geographic code, is Seyne. However, it is known at the local level as Seyne-les-Alpes, hitherto not endorsed by a decree. It is not to be confused with the town of La Seyne-sur-Mer which is the second town in the Var department.