塞皮诺（意大利语：Sepino），是意大利坎波巴索省的一个市镇。总面积62平方公里，人口2069人，人口密度33.4人/平方公里（2009年）。ISTAT代码为070075。

Sepino is a comune (municipality) in the Province of Campobasso in the Italian region Molise, located about 20 kilometres (12 mi) south of Campobasso.

The archaeological site of Saepinum is located nearby. Sepino borders the following municipalities: Cercemaggiore, ****, Guardiaregia, Morcone, Pietraroja, San Giuliano del Sannio, Sassinoro.