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单词 Selective estrogen receptor modulators
释义

Selective estrogen receptor modulators

英语例句库

Food and Drug Administration (FDA) has issued a second approvable letter for bazedoxifene, a selective estrogen receptor modulator, for the prevention of postmenopausal osteoporosis.

苯卓昔芬是一种选择性雌激素受体调节剂，为预防绝经后骨质疏松症药物。

原声例句
Osmosis-肌骨

Finally, medications like denosumab, which is a monoclonal antibody that inhibits osteoclasts, and raloxifene, which is a selective estrogen receptor modulator, can be used for postmenopausal osteoporosis.

最后，地诺单抗等药物作为单克隆抗体可抑制破骨细胞；雷洛昔芬，一种有选择性的雌激素受体调节器，可以被用于绝经后骨质疏松。

英语百科

Selective estrogen receptor modulator

（重定向自Selective estrogen receptor modulators）
Figure 1: Timeline of when SERMs came on the market.
Figure 2: Nolvadex (tamoxifen) 20-milligram tablets (UK)
Figure 3: The domain structures of ERα and ERβ, including some of the known phosphorylation sites involved in ligand-independent regulation.
Figure 4: Structural basis for the mechanism of estrogen receptor agonist and antagonist action.[17] The structures shown here are of the ligand binding domain (LBD) of the estrogen receptor (green cartoon diagram) complexed with either the agonist diethylstilbestrol (top, PDB: 3ERD​) or antagonist 4-hydroxytamoxifen (bottom, 3ERT​). The ligands are depicted as space filling spheres (white = carbon, red = oxygen). When an agonist is bound to a nuclear receptor, the C-terminal alpha helix of the LBD (H12; light blue) is positioned such that a coactivator protein (red) can bind to the surface of the LBD. Shown here is just a small part of the coactivator protein, the so-called NR box containing the LXXLL amino acid sequence motif.[18] Antagonists occupy the same ligand binding cavity of the nuclear receptor. However antagonist ligands in addition have a sidechain extension which sterically displaces H12 to occupy roughly the same position in space as coactivators bind. Hence coactivator binding to the LBD is blocked.

Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER). A characteristic that distinguishes these substances from pure ER agonists and antagonists (that is, full agonists and silent antagonists) is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in various tissues.
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更新时间：2025/6/19 8:27:21