美国纽约南区联邦地区法院（United States District Court for the Southern District of New York，在法律引用中缩写为“S.D.N.Y.”）是美国的一个联邦地区法院。本法院判决的案件如需上诉，需上诉至联邦第二巡回上诉法院，专利及《塔克法案》相关的案件需上诉至联邦巡回区法院。纽约南区法院是美国最有影响力、案件处理量最大的法院之一，因为纽约市（除布鲁克林、皇后区、斯塔滕岛，后三地属于东区）很多涉及联邦法的案件都要在此审理。现任首席法官为 Loretta Preska。

The United States District Court for the Southern District of New York (in case citations, S.D.N.Y.) is a federal district court. Appeals from the Southern District of New York are taken to the United States Court of Appeals for the Second Circuit (except for patent claims and claims against the U.S. government under the Tucker Act, which are appealed to the Federal Circuit).