屏幕阅读器（英语：screen reader）又称为屏幕报读软件，是一种安装于电脑上的应用程序软件，用来将文本、图形以及电脑接口的其他部分（藉文本转语音（Text-To-Speech, TTS）技术）转换成语音及／或点字。对于视障者或阅读障碍者甚有助益，有些人会搭配放大软件一齐使用。 屏幕阅读器至少可以读出：

当使用屏幕报读软件时，屏幕是否开启并不会影响其运作，它本身并不构成一部电脑的要件，只是一个软件或输出设备。

用户在挑选屏幕报读软件时，通常会考量许多因素。包含使用平台、成本、用户偏好等，并也会受到其所属组织（如慈善机构、学校、任职公司）之影响，而屏幕报读软件在选择上是备受争议的。

A screen reader is a software application that attempts to identify and interpret what is being displayed on the screen (or, more accurately, sent to standard output, whether a video monitor is present or not). This interpretation is then re-presented to the user with text-to-speech, sound icons, or a Braille output device. Screen readers are a form of assistive technology (AT) potentially useful to people who are blind, visually impaired, illiterate or learning disabled, often in combination with other AT, such as screen magnifiers.