Sarcosine dehydrogenase
![Figure 1: First step in sarcosine dehydrogenase catalyzed reaction mechanism[5]](/uploads/202502/09/Mechanism_1st_step_15153.png)
![Figure 3: Sarcosine going to glycine reaction mechanism with tetrahydrofolate (THF) present.[7]](/uploads/202502/09/Sarcosine_MechanismTHF5153.png)
![Figure 4: Sarcosine metabolism and related pathway.[14][15][16]](/uploads/202502/09/Sarcosine-glycine_pathway5153.png)
In enzymology, sarcosine dehydrogenase (EC1.5.8.3) is a mitochondrial enzyme that catalyzes the chemical reaction N-demethylation of sarcosine to give glycine. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donor with other acceptors. The systematic name of this enzyme class is sarcosine:acceptor oxidoreductase (demethylating). Other names in common use include sarcosine N-demethylase, monomethylglycine dehydrogenase, and sarcosine:(acceptor) oxidoreductase (demethylating). Sarcosine dehydrogenase is closely related to dimethylglycine dehydrogenase, which catalyzes the demethylation reaction of dimethylglycine to sarcosine. Both sarcosine dehydrogenase and dimethylglycine dehydrogenase use FAD as a cofactor. Sarcosine dehydrogenase is linked by electron-transferring flavoprotein (ETF) to the respiratory redox chain. The general chemical reaction catalyzed by sarcosine dehydrogenase is: