圣地亚哥（葡萄牙语：Santiago，意指圣雅各伯）是佛得角共和国最大的岛屿，面积达991平方公里，位于大西洋。圣地亚哥岛是该国最重要的农业中心。该国约一半人口居住该岛，首都普拉亚亦设在圣地亚哥岛。

圣地亚哥岛位于五月岛（Maio）和弗古（Fogo）之间。岛上的城镇Cidade Velha于1462年设立，因此圣地亚哥岛是佛得角群岛中最早有人居住的岛屿。自佛得角共和国独立（1975年）后，该岛人口增加了两倍。岛上产业主要是农业、旅游业、渔业，但制造业并不重要。岛上主要农产品为粟米、甘蔗、香蕉、咖啡和芒果。

Santiago (Portuguese for “Saint James”), or Santiagu in Cape Verdean Creole, is the largest island of Cape Verde, its most important agricultural centre and home to half the nation’s population.

Santiago is located between the islands of Maio (40 km west) and Fogo (50 km east) and is one of the Sotavento. It was the first of the islands to be settled, the town of Cidade Velha being founded as Ribeira Grande in 1462. It is also home to the nation's capital city of Praia and to one of the islands’ four international airports, Praia International Airport, 3 km from the capital (IATA airport code: RAI, Praia).