Santo Stefano Belbo is a comune (municipality) in the Province of Cuneo in the Italian region Piedmont, located about 60 kilometres (37 mi) southeast of Turin and about 60 kilometres (37 mi) northeast of Cuneo.

It is the birthplace of 20th century author Cesare Pavese. On its hill are a medieval castle and a Benedictine convent, most likely built on the ruins of a temple of Jupiter. The village of Santo Stefano Belbo of medieval origin stands between the Langhe hills. Around 1300 it was first a fief of the Marquises of Monferrato, then the Marchesi of Saluzzo,and then the family of Scarampi. The land was often a conflict as a demonstration of the ancient medieval tower, destroyed in the war between Spain and Austria in 1600. The economy of Santo Stefano Belbo relies mainly on the production of wine, especially the Moscato d'Asti and Asti Spumante.