死亡圣神（西班牙语：Santa Muerte，或西班牙语：Santísima Muerte，即是英语：Saint Death）是在墨西哥被敬奉的一种圣像，可能是产生于中美洲传统信仰与民间天主教信仰混杂之后的结果。

它通常是穿着长袍的骷髗，手上拿着大镰刀跟地球仪。

Nuestra Señora de la Santa Muerte or, colloquially, Santa Muerte (Spanish for Holy Death or Sacred Death), is a female folk saint venerated primarily in Mexico and the Southwestern United States. A personification of death, she is associated with healing, protection, and safe delivery to the afterlife by her devotees. Despite opposition by the Catholic Church, her cult arose from popular Mexican folk belief, a syncretism between indigenous Mesoamerican and Spanish Catholic beliefs and practices.