新圣母大殿（Basilica di Santa Maria Novella）是意大利佛罗伦萨的一座罗马天主教教堂，坐落在佛罗伦萨主要的火车站，同名的新圣母车站对面，按年代而言，这是佛罗伦萨第一座宗座圣殿，也是道明会在该市的主要教堂。

这座教堂、连同毗邻的修道院，由于佛罗伦萨最重要的家族的慷慨捐助，收藏了一批无价的艺术珍宝，特别以哥特式和早期文艺复兴大师的壁画而着称。

Santa Maria Novella is a church in Florence, Italy, situated just across from the main railway station which shares its name. Chronologically, it is the first great basilica in Florence, and is the city's principal Dominican church.

The church, the adjoining cloister, and chapterhouse contain a store of art treasures and funerary monuments. Especially famous are frescoes by masters of Gothic and early Renaissance. They were financed through the generosity of the most important Florentine families, who ensured themselves of funerary chapels on consecrated ground.