圣帕布罗湾（英语：San Pablo Bay）是美国加州中部的一个河口湾，毗邻旧金山湾。其水深浅，但在湾的中间有一条深水信道，因此能让航运通往加州首府沙加缅度、史塔克顿等地。

其水源主要来自上游由沙加缅度河与圣华金河所汇聚而成的色逊湾，下游接续旧金山湾，并从金门大桥处出海至东太平洋。沙加缅度河与圣华金河的流域则涵盖加州中部的中央谷地。此外也吸纳纳帕河与索诺马溪等河川的水源。圣帕布罗湾的跨径约10 mi（16 km），面积则约90 sq mi（230 km）。

San Pablo Bay is a tidal estuary that forms the northern extension of San Francisco Bay in the East Bay and North Bay regions of the San Francisco Bay Area in northern California.

Most of the Bay is shallow; however, there is a deep water channel approximately in the middle of the bay, which allows access to major ports in Sacramento, Stockton, Benicia, and Martinez; and other smaller ports on the Sacramento–San Joaquin River Delta.