圣马尔谷圣殿宗主教座堂（意大利语：Basilica Cattedrale Patriarcale di San Marco；基督教译：圣马可大教堂）是意大利威尼斯的天主教主教座堂，也是天主教的宗座圣殿，是世界上知名的教堂之一，并且是拜占庭式建筑的著名代表。圣马可大教堂座落在圣马可广场东面，与总督宫相连。最初它是威尼斯公爵的教堂，1807起它成为天主教威尼斯总教区的主座教堂，同时是威尼斯宗主教的驻地。

The Patriarchal Cathedral Basilica of Saint Mark (officially known in Italian as the Basilica Cattedrale Patriarcale di San Marco and commonly known as Saint Mark's Basilica) is the cathedral church of the Roman Catholic Archdiocese of Venice, northern Italy. It is the most famous of the city's churches and one of the best known examples of Italo-Byzantine architecture. It lies at the eastern end of the Piazza San Marco, adjacent and connected to the Doge's Palace. Originally it was the chapel of the Doge, and has only been the city's cathedral since 1807, when it became the seat of the Patriarch of Venice, archbishop of the Roman Catholic Archdiocese of Venice, formerly at San Pietro di Castello.