Sambuca di Sicilia (Sicilian: Sammuca) is a comune (municipality) in the Province of Agrigento in the Italian region Sicily, located about 68 kilometres (42 mi) southwest of Palermo and about 89 kilometres (55 mi) northwest of Agrigento. As of 31 December 2010, it had a population of 6207 and an area of 95.88 square kilometres (37.02 sq mi).