索尔克生物研究所（英语：Salk Institute for Biological Studies，又译为沙克生物学研究所）是坐落在加州南部拉霍亚的一个独立非营利科学研究机构。它于1960年由乔纳斯·索尔克创立，创始者中有雅各布·布罗诺斯基和弗朗西斯·克里克。1962年研究所正式投入运行。这所研究所是美国生命科学领域成果最多、质量最高的研究机构之一。 2004年，时代高等教育增刊将索尔克研究所列为世界第一的生物医学研究机构，2009年，科学观察将其列为神经科学和行为学领域全球第一的研究所。

The Salk Institute for Biological Studies is an independent, non-profit, scientific research institute located in La Jolla, San Diego, California, United States. It was founded in 1960 by Jonas Salk, the developer of the polio vaccine; among the founding consultants were Jacob Bronowski and Francis Crick. Building did not start until spring of 1962. The institute consistently ranks among the top institutions in the US in terms of research output and quality in the life sciences. In 2004, the Times Higher Education Supplement ranked Salk as the world's top biomedicine research institute, and in 2009 it was ranked number one globally by ScienceWatch in the neuroscience and behavior areas.