圣克莱尔河（St. Clair River）位于北美洲中部五大湖地区，连接休伦湖和圣克莱尔湖，全长64公里。

The St. Clair River is a 40.5-mile-long (65.2 km) river in central North America which drains Lake Huron into Lake St Clair, forming part of the international boundary between the Canadian province of Ontario and the U.S. state of Michigan. The river is a significant component in the Great Lakes Waterway, with shipping channels permitting cargo vessels to travel between the upper and lower Great Lakes.