Robalzotan

Robalzotan (NAD-299, AZD-7371) is a selective antagonist at the 5-HT_1A receptor. It was shown to completely reverse the autoreceptor-mediated inhibition of serotonin release induced by the administration of selective serotonin reuptake inhibitors like citalopram in rodent studies. It was subsequently investigated by AstraZeneca as a potential antidepressant but like many other 5-HT_1A ligands was discontinued. Later on it was researched for other indications such as irritable bowel syndrome but was dropped once again.

单词	Robalzotan
释义	Robalzotan 英语百科 Robalzotan Robalzotan (NAD-299, AZD-7371) is a selective antagonist at the 5-HT_1A receptor. It was shown to completely reverse the autoreceptor-mediated inhibition of serotonin release induced by the administration of selective serotonin reuptake inhibitors like citalopram in rodent studies. It was subsequently investigated by AstraZeneca as a potential antidepressant but like many other 5-HT_1A ligands was discontinued. Later on it was researched for other indications such as irritable bowel syndrome but was dropped once again.
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