Regulatory enzyme

Chymotrypsinogen (the precursor of Chymotrypsin). Painted in red the residue ILE16 and in green the residue ARG15 both involved in the enzyme activation. In dark blue the residue ASP 194 that will later interact with ILE 16.

Gamma-Chymotrypsin. In red the residue ILE16 that is now interacting with ASP194, in dark blue. First step of the enzyme activation: the peptide bond ARG15-ILE16 has been hydrolyzed releasing the ILE16 amine, positively charged in physiologic conditions. The amine will strongly interact with the negatively charged radical from ASP194, an ionic bond will be established.

Gamma-Chymotrypsin, a complex of Alpha-Chymotrypsin. Images modified from pdb

A regulatory enzyme is an enzyme in a biochemical pathway which, through its responses to the presence of certain other biomolecules, regulates the pathway activity. This is usually done for pathways whose products may be needed in different amounts at different times, such as hormone production. Regulatory enzymes exist at high concentrations (low Vmax) so their activity can be increased or decreased with changes in substrate concentrations.

单词	Regulatory enzyme
释义	Regulatory enzyme 英语百科 Regulatory enzyme A regulatory enzyme is an enzyme in a biochemical pathway which, through its responses to the presence of certain other biomolecules, regulates the pathway activity. This is usually done for pathways whose products may be needed in different amounts at different times, such as hormone production. Regulatory enzymes exist at high concentrations (low Vmax) so their activity can be increased or decreased with changes in substrate concentrations.
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