还原胺化反应




还原胺化反应,又称鲍奇还原(Borch reduction,区别于伯奇Birch还原反应),是一种简便的把醛酮转换成胺的方法。
首先是胺与羰基加成,缩合,生成羰基的结构类似物西弗碱(Schiff Base),后者接受氢供体的氢传递生成最终产物胺。见图:

单词 | Reductive amination |
释义 |
Reductive amination
中文百科
还原胺化反应![]() ![]() ![]() ![]() 还原胺化反应,又称鲍奇还原(Borch reduction,区别于伯奇Birch还原反应),是一种简便的把醛酮转换成胺的方法。
首先是胺与羰基加成,缩合,生成羰基的结构类似物西弗碱(Schiff Base),后者接受氢供体的氢传递生成最终产物胺。见图: ![]()
英语百科
Reductive amination 还原胺化反应![]() ![]() ![]() ![]() Reductive amination (also known as reductive alkylation) is a form of amination that involves the conversion of a carbonyl group to an amine via an intermediate imine. The carbonyl group is most commonly a ketone or an aldehyde. It is considered the most important way to make amines, and a majority of amines made in the pharmaceutical industry are made this way. |
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