西布曲明（Sibutramine），化学名(±)N-(1-(1-(4-氯苯基)环丁基)-3-甲基丁基)-N,N-二甲胺，化学式C₁₇H₂₆ClN，是一种作用于中枢神经系统的食欲抑制剂，其化学结构与安非他命有点关连，但作用机理不同。它在医学上可作为一种口服的减肥药，通常使用盐酸西布曲明（Sibutramine Hydrochloride，C₁₇H₂₆ClN·HCl·H₂O）生产药品。

该药由美国雅培制药研发，商品名Reductil（诺美婷）、Meridia。

Sibutramine (usually in the form of the hydrochloride monohydrate salt) is an oral anorexiant. Until 2010 it was marketed and prescribed as an adjunct in the treatment of exogenous obesity along with diet and exercise. It has been associated with increased cardiovascular events and strokes and has been withdrawn from the market in several countries and regions including Australia, Canada, China, the European Union (EU), Hong Kong, India, Mexico, New Zealand, the Philippines, Thailand, the United Kingdom, and the United States.