The same JNK1 gets stimulated which promotes inflammation and JNK1 acts on the same IRS-1 insulin receptor causing insulin resistance in the liver.

和之前一样，JNK1 被激活，导致炎症。JNK1 作用于 IRS-1 受体，导致胰岛素抗性。

The insulin will stimulate this insulin receptor IRS-1, which causes a series of reactions to then stimulate SREBP1 and activate this enzyme called glucokinase.

胰岛素会刺激胰岛素受体 IRS-1，这会导致一系列的反应，从而刺激 SREBP1，并激活一个叫做葡萄糖激酶的酶。