伊利沙伯皇后道（英语：Queen Elizabeth Way，简称QEW、Q、QE或Queen-E，官方年报称为451号省道）是加拿大安大略省南部一条400系列高速公路，连接该省首府多伦多和位于尼亚加拉半岛东南角的伊利堡，并在该处驳上和平桥横跨尼亚加拉河，与对岸美国水牛城的190号州际公路相连。公路全长139公里，从伊利堡起途经尼亚加拉瀑布城、圣嘉芙莲斯、咸美顿、伯灵顿、奥克维尔和密西沙加等城镇，在多伦多的终点处与427号公路和嘉甸拿高速公路交汇，当中在荷顿区内约长22公里（14英里）的路段则与403号公路共构。

The Queen Elizabeth Way (QEW) is a 400-series highway in the Canadian province of Ontario linking Toronto with the Niagara Peninsula and Buffalo, New York. The freeway begins at the Peace Bridge in Fort Erie and travels 139.1 kilometres (86.4 mi) around the western shore of Lake Ontario, ending at Highway 427. The physical highway, however, continues as the Gardiner Expressway into downtown Toronto. The QEW is one of Ontario's busiest highways, with an average of close to 200,000 vehicles per day on some sections. Major highway junctions are located at Highway 420 in Niagara Falls, Highway 405 in Niagara-on-the-Lake and Highway 406 in St. Catharines, the Red Hill Valley Parkway in Hamilton, Highway 403 and Highway 407 in Burlington, Highway 403 at the Oakville–Mississauga boundary and Highway 427 in Etobicoke. Within the Regional Municipality of Halton, the QEW is signed concurrently with Highway 403.