The African rock python (Python sebae) is a large, nonvenomous snake of sub-Saharan Africa. It is one of 11 living species in the genus Python. It has two subspecies; one is found in Central and Western Africa, the other in Southern Africa.

Africa's largest snake and one of the six largest snake species in the world (along with the green anaconda, reticulated python, Burmese python, Indian python, and amethystine python), specimens may approach or exceed 6 m (20 ft). The southern subspecies is generally smaller than its northern relative. The snake is found in a variety of habitats, from forests to near deserts, although usually near sources of water. The African rock python kills its prey by constriction and often eats animals up to the size of antelope, occasionally even crocodiles. The snake reproduces by egg-laying. Unlike most snakes, the female protects her nest and sometimes even her hatchlings.