Amyloid beta

（重定向自Aβ）

Micrograph showing amyloid beta (brown) in senile plaques of the cerebral cortex (upper left of image) and cerebral blood vessels (right of image) with immunostaining.

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The seeds or the resulting amyloid plaques are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.

单词	Aβ
释义	Aβ 英语百科 Amyloid beta （重定向自Aβ） Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The seeds or the resulting amyloid plaques are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.
随便看	Litsea euosma的意思 Litsea euosma W.W.Sm.的意思 litsea euosma w. w. smith的意思 litsea faberi hemal.的意思 Litsea forrestii的意思 Litsea foveolata的意思 Litsea garciae的意思 Litsea garrettii的意思 Litsea glauca的意思 Litsea globosa的意思 Litsea glutinosa的意思 Litsea gongshanensis的意思 Litsea greenmaniana的意思 Litsea hayatae的意思 Litsea honghoensis的意思 Litsea hunanensis的意思 Litsea hupehana的意思 Litsea hypophaea的意思 Litsea ichangensis的意思 litsea ichangensis gamble的意思 Litsea kobuskiana的意思 Litsea kostermansii的意思 Litsea krukovii的意思 Litsea kwangsiensis的意思 Litsea kwangtungensis的意思