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单词 Protein protein interaction
释义

Protein protein interaction

中文百科

蛋白质交互作用 Protein–protein interaction

(重定向自Protein protein interaction)
核糖核酸酶抑制剂(马蹄形)与核糖核酸酶蛋白的交互作用。其彼此间的链接经软件着色。
Crystal structure of modified Gramicidin S horizontally determined by X-ray crystallography
NMR structure of cytochrome C illustrating its dynamics in solution
Principles of yeast and mammalian two-hybrid systems

蛋白质交互作用(Protein–protein interactions (PPIs))是指两种或以上的蛋白质结合的过程,通常旨在运行其生化功能。在细胞中,大量蛋白质组件组成分子机器,透过蛋白质交互作用运行细胞内多数重要的分子过程,如DNA复制。

蛋白质交互作用在绝大多数生化功能中扮演极重要的角色。例如,信号分子经由蛋白质交互作用,将细胞外部的信号传入内部。这个过程称为消息传递,是许多生化功能的基础,也与许多疾病有关,包括癌症。蛋白质亦可透过长时间的交互作用,形成部分的蛋白质复合体,负责携带另一个蛋白质,例如从细胞质至细胞核,或反之,如核孔核转运蛋白的情形;或借由短暂的交互作用修饰另一个蛋白质,例如负责将磷酸盐转移到目标蛋白上的蛋白激酶。蛋白质经修饰后也可能改变其蛋白质交互作用,例如有些SH2结构域的蛋白质只与其他被胺基酸酪胺酸磷酸化的蛋白质结合,布罗莫结构域则专门辨别乙酰离胺酸。

英语百科

Protein–protein interaction 蛋白质交互作用

(重定向自Protein protein interaction)
The horseshoe shaped ribonuclease inhibitor (shown as wireframe) forms a protein–protein interaction with the ribonuclease protein. The contacts between the two proteins are shown as coloured patches.
Crystal structure of modified Gramicidin S horizontally determined by X-ray crystallography
NMR structure of cytochrome C illustrating its dynamics in solution
Principles of yeast and mammalian two-hybrid systems

Protein–protein interactions (PPIs) refer to lasting and specific physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces. Commonly they are understood as physical contacts with molecular docking between proteins that occur in a cell or in a living organism in specific biomolecular contexts.

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更新时间:2025/6/17 19:48:14