As I mentioned earlier, inflammation also seems to be involved, and there are a number of proinflammatory cytokines like IL-1, IL-6, and TNF, among others, that seem to play a role.

如之前提到的，炎症反应可能有参与病程，其中一些炎症因子如IL-1、IL-6与TNF可能在炎症反应中起作用。

When the abnormal IgA1-IgG immune complexes deposit in the mesangium, the alternative complement pathway is activated, leading to the release of proinflammatory cytokines and migration of macrophages into the kidney, all of which contributes to glomerular injury.

当异常的IgA1-IgG免疫复合物沉积在系膜上时，补体旁路途径被激活，导致促炎因子的释放，同时促进巨噬细胞向肾迁移，以上所有反应会导致肾小球的损伤。

As " type A" cells in the synovium attempt to remove the debris, immune cells like lymphocytes and macrophages are recruited into the synovial membrane, which produces proinflammatory cytokines that ultimately cause inflammation of the synovium as well, called synovitis.

滑膜上的A型细胞努力清除这些碎片的同时，免疫细胞（如淋巴细胞、巨噬细胞）也被募集进入滑膜，产生炎症因子，最终导致滑膜炎。