Nonsense mutation
(重定向自Premature stop codon)
![Selection of notable mutations, ordered in a standard table of the genetic code of amino acids.[2] Nonsense mutations are marked by red arrows.](/uploads/202502/04/Notable_mutations.svg0907.png)
In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon in the transcribed mRNA, and in a truncated, incomplete, and usually nonfunctional protein product. It differs from a missense mutation, which is a point mutation where a single nucleotide is changed to cause substitution of a different amino acid. Some genetic disorders, such as thalassemia and DMD, result from nonsense mutations.