Progeroid syndromes

（重定向自Premature aging）

Werner syndrome is inherited in an autosomal recessive manner, which means both parents must contribute a dysfunctional allele for an individual to develop the disease.

An eight-year-old girl from Guatemala with xeroderma pigmentosum. Children with XP are often colloquially referred to as Children of the Night.[49]

Lamin is required at the inner nuclear membrane to ensure the nucleus keeps its shape. Mutations in LMNA causes dysfunctional lamin, and the nucleus can no longer keeps its shape. This leads to mislocalisation of heterochromatin, which normally lie in close proximity, or with, the nuclear matrix, nuclear blebbing and misregulation of gene expression.

Girl with HGPS (left). This condition is caused by dysfunctional lamin which is unable to maintain the nuclear shape (normal at top, abnormal at bottom)

Progeroid syndromes (PS) are a group of rare genetic disorders that mimic physiological aging, making affected individuals appear to be older than they are. The term progeroid syndrome does not necessarily imply progeria (Hutchinson-Gilford progeria syndrome), which is a specific type of progeroid syndrome.

单词	Premature aging
释义	Premature aging 原声例句双语版 TED-Ed 演讲精选 Along with cigarette smoking, sun damage is the leading cause of premature aging. 除了吸烟以外，阳光伤害是造成提早老化的主因。假如有如果 This would result in the premature aging of the “new” galaxy as it used up its fuel. 这会导致“新”星系耗尽燃料而过早老化。科普小杂文 Remember, it's important to wear a sunscreen all year around to protect yourself from skin cancer and premature aging. 记住，一年四季都要涂抹防晒，以防止皮肤癌和过早衰老。 Scishow 精选系列 It doesn't have to show protection against UVA radiation, which causes wrinkles, premature skin aging, and again, skin cancer. 但是不代表能够预防可以导致皮肤老化、皱纹、引发皮肤癌的 UNA 射线。 2011 ESLPod Wait a minute… no, actually I am in my late 40s, so maybe I'm not premature aging. 等一下… … 不，实际上我已经 40 多岁了，所以也许我没有过早衰老。 2011 ESLPod Well, " premature aging" would be getting older before you should be getting older, or you look older than you should. 好吧，“过早衰老” 会在你应该变老之前变老，或者你看起来比你应该变老。历年六级阅读真题精听 The foods you eat, your response to challenges, the amount of exercise you get, and many other factors appear to influence your telomeres and can prevent premature aging at the cellular level. 你吃的食物，你对挑战的反应，你得到的运动量，以及许多其他因素似乎会影响你的端粒，并能在细胞水平上防止过早衰老。英语百科 Progeroid syndromes （重定向自Premature aging） Progeroid syndromes (PS) are a group of rare genetic disorders that mimic physiological aging, making affected individuals appear to be older than they are. The term progeroid syndrome does not necessarily imply progeria (Hutchinson-Gilford progeria syndrome), which is a specific type of progeroid syndrome.
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