多孔菌科（拉丁语学名：Polyporaceae）是担子菌门中的一个科。

多孔菌科菌类的菌髓柔软到坚韧。大多数多孔菌科菌类在菌伞的下方带孢子，但是也有些种有菌褶或者类似菌褶的结构。孢子粉为白色，没有囊状体。有些种有柄，也有些没有，或者菌伞是横出来的。许多种有阶状的结构。

大多数多孔菌科菌类是死木上的腐生生物，有些种也寄生在活着的树上。

大多数多孔菌科菌类不可食，少数可食的种包括硫磺孔菌（Laetiporus sulphureus）和宽鳞多孔菌（Polyporus squamosus），这两种菌在嫩的时候可食。中医中使用一些多孔菌科菌类作为中药，比如白腐担子菌（Trametes versicolor）、猪苓（Polyporus umbellatus）和木蹄层孔菌（Fomes fomentarius）。

The Polyporaceae are a family of bracket fungi belonging to the Basidiomycota. The flesh of their fruiting bodies varies from soft (as in the case of the Dryad's Saddle illustrated) to very tough. Most members of this family have their hymenium (fertile layer) in vertical pores on the underside of the caps, but some of them have gills (e.g. Panus) or gill-like structures (such as Daedaleopsis, whose elongated pores form a corky labyrinth). Many species are brackets, but others have a definite stipe - for example: Polyporus badius.