多囊性肾病变（英语：polycystic kidney disease），又称多囊肾、泡泡肾，多囊性肾病变是一种遗传病的肾病变，人、猫、狗等多种动物都可能发病，其中猫的发病率高达6%。

人类的多囊性肾病变可分成两种，第一种是多囊性肾病变一型，是由第16对染色体变性引起；而另一种是多囊性肾病变二型，是第4对染色体变性引起。病患者的肾脏会长出许多囊肿，令病患者的肾体积骤增及肾功能减退。多囊性肾病变是十分常见的遗传病之一。统计数字显示，其发病率为万分之一，即每万人就有一人患此症。当中有百分之九十是多囊性肾病变一型，其余的百分之十是多囊性肾病变二型。

Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which abnormal cysts develop and grow in the kidneys. Cystic disorders can express themselves at any point, infancy, childhood, or adulthood. The disease occurs in humans and some other animals. PKD is characterized by the presence of multiple cysts (hence, "polycystic") typically in both kidneys; however, 17% of cases initially present with observable disease in one kidney, with most cases progressing to bilateral disease in adulthood.