西北太平洋国家实验室(英语：Pacific Northwest National Laboratory ，简称：PNNL )，创建于1965年，位于美国华盛顿州东部哥伦比亚河和亚基马河交界的沙漠地带，在第二次世界大战“曼哈顿工程”里生产美国原子弹核材料的汉福德基地的基础上建成。PNNL最初的任务是从事原子弹核材料生产的研究，20世纪80年代末开始从事整个基础科学研究。PNNL隶属于美国能源部，现拥有4000多名科学家。其优势研究领域包括能源、环境、计算机、核能、放射化学等，特别是基础分子科学和计算机科学。

Pacific Northwest National Laboratory (PNNL) is one of the United States Department of Energy national laboratories, managed by the Department of Energy's Office of Science. The main campus of the laboratory is in Richland, Washington.

PNNL scientists conduct basic and applied research and development to strengthen U.S. scientific foundations for fundamental research and innovation; prevent and counter acts of terrorism through applied research in information analysis, cyber security, and the nonproliferation of weapons of mass destruction; increase the U.S. energy capacity and reduce dependence on imported oil; and reduce the effects of human activity on the environment. PNNL has been operated by Battelle Memorial Institute since 1965.