比尔森州 (捷克语:Plzeňský kraj;德语:Region Pilsen)，是捷克西部的一个州，历史上属于波希米亚。面积7,561 平方公里，人口562 766 (2006年)。首府比尔森。下分七区。

捷克行政区划 中波希米亚 赫拉德茨-克拉洛韦 卡罗维发利 利贝雷茨 摩拉维亚-西里西亚 奥洛穆克 帕尔杜比采 比尔森 布拉格 南波希米亚 南摩拉维亚 乌斯季 维索基纳 兹林

Plzeň Region (Czech:Plzeňský kraj) is an administrative unit (kraj) in the western part of Bohemia in the Czech Republic. It is named after its capital Plzeň (English Pilsen, German:Pilsen). In terms of area, Plzeň region is with 7,561 km the third largest region in the Czech Republic. However, with the population of 572,459 inhabitants (as of 31 December 2012) it was the ninth most populous region. After the South Bohemian Region it is the second least densely populated region. The region can be roughly divided into two parts: a highly industrialized north-eastern part with a strong engineering tradition around Pilsen (Czech:Plzeň) and a more hilly and rural south-western part with smaller-sized manufacturing companies processing natural resources.