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单词 Plavix
释义

Plavix

中文百科

氯吡格雷 Clopidogrel

(重定向自Plavix)
氯吡格雷
Una caja de


氯吡格雷(Clopidogrel,商品名为波立维(中国大陆)、保栓通(**)(Plavix),分子式:C16H16ClNO2S,莫耳质量:321.82g/mol),是抑制血小板聚集的药物。

不良反应可有皮疹、腹泻、腹痛、消化不良、颅内出血、消化道出血,严重粒细胞减少。怀孕期间不建议服用此药。

1,3-茚满二酮: 氯茚二酮 · 二苯茚酮 · 苯茚二酮

低聚木糖(磺达肝癸钠、艾卓肝素)

其他丝氨酸内肽酶: 安克洛酶 · 溶纤维蛋白酵素

英语百科

Clopidogrel 氯吡格雷

(重定向自Plavix)
Clopidogrel (top left) being activated: The first step is an oxidation mediated (mainly) by CYP2C19, unlike the activation of the related drug prasugrel. The two structures at the bottom are tautomers of each other; and the final step is a hydrolysis. The active metabolite (top right) has Z configuration at the double bond C3–C16 and possibly R configuration at the newly asymmetric C4.[26]
A box of Plavix

Clopidogrel (INN) is an oral, thienopyridine-class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, cerebrovascular disease, and to prevent myocardial infarction (heart attack) and stroke. It is marketed by Bristol-Myers Squibb and Sanofi under the trade name Plavix. The drug works by irreversibly inhibiting a receptor called P2Y12, an adenosine diphosphate (ADP) chemoreceptor on platelet cell membranes. Adverse effects include bleeding and thrombotic thrombocytopenic purpura.

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更新时间:2025/6/17 6:28:47