Instead, the pituitary adenoma simply grows in size and secretes too much ACTH.

相反，垂体腺瘤只会增大，并分泌过多的ACTH。

In some cases, Cushing syndrome results from a pituitary adenoma making excess ACTH, and in those situations it's called Cushing disease.

在某些病例中，库欣综合征是由垂体腺瘤制造过多促肾上腺皮质激素导致的；在这种情况下，它被称作库欣病。

Unlike pituitary adenomas, ectopic sites of ACTH productions typically don't respond even to high doses of dexamethasone, and the serum cortisol remains high.

和垂体腺瘤不同，异位ACTH综合征一般对高剂量地塞米松没有反应，血清皮质醇还是会很高。

The leading cause of that is a pituitary adenoma, which is a benign tumor of the pituitary gland- and this specific condition is called Cushing disease.

垂体腺瘤是导致这一失常的主要原因，这是一种位于垂体的良性肿瘤，在这种特定情况下被称为库欣病。

Apart from pituitary adenomas, there are ectopic sources of ACTH like small cell lung cancer, and in these cases the excess ACTH is coming from somewhere other than the pituitary.

除了垂体腺瘤，ACTH也有异位来源，比如小细胞肺癌；在这种情况下，垂体以外的部位分泌过多的ACTH。

It can be exogenous, meaning drug-related, or endogenous, meaning that it's from an adrenal tumor or excess ACTH from a pituitary adenomas, in which case it's called Cushing disease or from an ectopic site like small cell lung cancer.

它可以是外源性，也就是药物相关；或内源性，也就是由肾上腺肿瘤或由垂体腺瘤分泌过多ACTH造成，这种情况下叫做库欣病，或是源于异位分泌，比如小细胞肺癌。