皮耶罗·德拉·弗朗切斯卡（Piero della Francesca，－1492年10月12日），意大利文艺复兴早期画家。弗朗切斯卡是皮鞋制造商的儿子，早年收到优良教育，1439年与人合作为佛罗伦萨新圣母医院创作力湿壁画组画。1445年受托创作《慈悲之圣母》组画，1452年又为阿雷佐圣方济各教堂创作了湿壁画《十字架传奇》。弗朗切斯卡的大部分时间待在佛罗伦萨和桑塞波尔克罗，有时也在里米尼、阿雷佐、费拉拉和罗马工作。

弗朗切斯卡生前享有盛誉，许多富商都到他那里订画，然而死后被人遗忘，直到20世纪才被人重新发现。他写了大量关于数学和透视法的文章，精准的线性透视法是其作品的主要特色。他的许多作品都是花大量时间完成，背景刻画十分细致，光线清晰，空间距离感得到适当强调，构图匀称，对当时的绘画有革命性的影响。

Piero della Francesca (Italian pronunciation: [ˈpjɛːro della franˈtʃeska]  listen ; c. 1415 – 12 October 1492) was an Italian painter of the Early Renaissance. As testified by Giorgio Vasari in his Lives of the Most Excellent Painters, Sculptors, and Architects, to contemporaries he was also known as a mathematician and geometer. Nowadays Piero della Francesca is chiefly appreciated for his art. His painting was characterized by its serene humanism, its use of geometric forms and perspective. His most famous work is the cycle of frescoes The History of the True Cross in the church of San Francesco in the Tuscan town of Arezzo.