佛波醇-12-十四烷酰-13-乙酸酯 (12-O-Tetradecanoylphorbol-13-acetate,TPA)是一种具有潜在促癌作用的佛波酯，在生物医学研究中常用作蛋白激酶C(Protein kinase C,PKC)的激活剂。 TPA对PKC的生物学活性源于它的拟甘油二酯(Diglyceride)样作用——后者是一种经典蛋白激酶C的天然活化剂。

在自由基生物学中，不包含羟基自由基、过氧化氢、过氧亚硝酸盐在内的超氧化物被认定系TPA而非离子霉素（Ionomycin）在小鼠巨噬细胞中产生的活性氧衍生物，因此TPA已成为诱生内源性超氧化物的常规用剂。

12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13-acetate (PMA), is a diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC result from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol. TPA is a small molecule drug.