Deuterated perlolyrine was synthesizedstarting from deuterated tryptophan via acid-catalyzed ring-closure, aromatisationand hydrolysis, with a yield of 11.

以色氨酸和氘水反应合成的氘标色氨酸为原料，经环化、氧化脱羧及水解等反应合成氘标川芎哚，产率为11。