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单词 PDGFR
释义

PDGFR

中文百科

血小板衍生生长因子受体 Platelet-derived growth factor receptor

(重定向自PDGFR)

血小板衍生生长因子受体(Platelet-derived growth factor receptors,PDGF-R)为血小板衍生生长因子(PDGF)蛋白质家族的受体,位于细胞膜表面,属于酪胺酸激酶受体的一种。PDGF的次单元A和次单元B在调控细胞增殖、分化、生长、发育上扮演相当重要的角色。如果调控不正常,可能会引发癌症等多种疾病。


PDGF-R有两种型态,分别为A和B,两种型态来自于不同基因。由于PDRF-R必须由两者结合成为双体之后才能作用,因此PDGFRA和PDGFRB可以互相组合或自我组合为均聚物(homodimerizes,即A配A、B配B)或杂二聚物(heterodimerizes,即A配B)

英语百科

Platelet-derived growth factor receptor 血小板衍生生长因子受体

(重定向自PDGFR)

Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGF-R, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes.

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更新时间:2025/6/17 15:32:38