牙鲆科是辐鳍鱼纲鲽亚目的其中一科。

牙鲆科下分15个属，如下：

Large-tooth flounders or sand flounders are a family, Paralichthyidae, of flounders. The family contains 14 genera with a total of about 110 species. They lie on the sea bed on their right side; both eyes are on the left side of the head, while the Pleuronectidae are the opposite with their eyes on the right side.