太平洋十二校联盟（Pacific-12 Conference）是一个美国西部的大学体育联盟。

这个联盟的成立可追溯至1915年12月15日在波特兰所举行的一次会议，会中创建了太平洋十大学联会的前身「太平洋海岸联盟」（Pacific Coast Conference，简写为PCC），创始成员为柏克莱加大、华盛顿大学、奥勒冈大学、奥勒冈州州立学院（Oregon State College，后来改为奥勒冈州州立大学）等四所学校。从1916年开始有盟校之间的体育竞赛及交流活动，1917年华盛顿州州立学院（Washington State College，后来改为华盛顿州州立大学）加盟，1918年史丹佛大学也加入PCC。1922年，南加大与爱达荷大学（U of Idaho）加盟，1924年，蒙大拿大学（U of Montana）加盟，1928年，UCLA获准加盟后，PCC扩增为十所学校。

The Pac-12 Conference is a collegiate athletic conference that operates in the Western United States. It participates in 22 NCAA sports in the NCAA's Division I; its football teams compete in the Football Bowl Subdivision (FBS; formerly Division I-A), the higher of two levels of NCAA Division I football competition. The conference's 12 members are located in Arizona, California, Colorado, Oregon, Utah, and Washington. They include each state's flagship public university, four additional public universities, and two private research universities. The conference was created after the disbanding of the Pacific Coast Conference (PCC), whose principal members founded the Athletic Association of Western Universities (AAWU) in 1959, and went by the names Big Five, Big Six, Pacific-8, Pacific-10. It became the Pac-12 in 2011 with the addition of the University of Colorado and the University of Utah.