8-Oxoguanine

8-oxoG (syn) in a Hoogsteen base pair with dA (anti)

For comparison here is a standard (non-mutagenic) GC base pair with both bases in the anti configuration of the bond between base and sugar.

8-Oxoguanine (8-hydroxyguanine, 8-oxo-Gua, or OHGua) is one of the most common DNA lesions resulting from reactive oxygen species and can result in a mismatched pairing with adenine resulting in G to T and C to A substitutions in the genome. In humans, it is primarily repaired by DNA glycosylase OGG1. It can be caused by ionizing radiation, in connection with oxidative metabolism.

单词	Oxoguanine
释义	Oxoguanine 英语百科 8-Oxoguanine 8-Oxoguanine (8-hydroxyguanine, 8-oxo-Gua, or OHGua) is one of the most common DNA lesions resulting from reactive oxygen species and can result in a mismatched pairing with adenine resulting in G to T and C to A substitutions in the genome. In humans, it is primarily repaired by DNA glycosylase OGG1. It can be caused by ionizing radiation, in connection with oxidative metabolism.
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