欧托-曼格语系是一个包含多个美洲原住民语言的大语系。现在只有墨西哥的原住民仍然在使用着。但是在过去，欧托-曼格语系的Manguean最南分布到尼加拉瓜与哥斯达黎加。现在使用人数最多的两个语支是位于瓦哈卡州的Zapotecan与Mixtecan，合共约150万人。在墨西哥中部，特别是在墨西哥州、伊达尔戈州与克雷塔罗州有约50万人在使用欧托-曼格语系的Otomi和十分接近的Mazahua语言。一些欧托-曼格语系语言正频临灭绝。例如，Ixcatec与Matlatzinca这两个语言各剩下不到250人的使用人口，而且绝大部分是老年人。其他的位于墨西哥以外的Manguean语言已经灭绝，当中包括Chiapanec语言，这是最近才宣布灭绝的。而与Me'phaa最接近的灭绝语言Subtiaba，只有在20世纪初才有过它的记述。

Oto-Manguean languages (also Otomanguean) are a large family comprising several subfamilies of Native American languages. All of the Oto-Manguean languages that are now spoken are indigenous to Mexico, but the Manguean branch of the family, which is now extinct, was spoken as far south as Nicaragua and Costa Rica. Oto-Manguean is widely viewed as a proven language family. However, this status has been recently challenged (Brown 2015).