Still in his mid-50s, he suffered severe osteoarthritis.

50多岁的时候， 他就备受骨关节炎的折磨。

Even the most common type, osteoarthritis, is trickier to prevent than one might think.

即使要避免最常见的骨关节炎，也比人们想象的难得多。

Osteoarthritis is really common, and nearly everyone knows someone that suffers from it.

骨关节炎十分常见，几乎每个人身边都有该病患者。

Which can boost the risk of osteoarthritis and the need for hip replacement in middle age.

这会增加骨关节炎的发病率从而使得患病者在中年时需要进行髋关节置换手术。

The origins of osteoarthritis can often be traced to a patient's early life, from any seemingly ordinary joint injury.

骨关节炎的病根，通常可追溯到患者早些年看似普通的关节损伤。

And they actually randomized these women who had knee osteoarthritis into one of two groups.

戴维斯：他们实际上将这些患有膝骨关节炎的女性随机分为两组。

We have, for example, an epidemic of osteoarthritis today.

例如，我们今天有流行的骨关节炎。

Nowadays, it's thought that inflammation does indeed play an important role in the development of osteoarthritis.

现如今，炎症反应被认为确实在骨关节炎病程发展中，起到了不可忽视的作用。

The researchers looked for signs of diabetes, high blood pressure, and osteoarthritis.

研究人员寻找糖尿病、高血压和骨关节炎的迹象。

Dolly who had to be put down in 2003 had aged prematurely because she developed osteoarthritis at a relatively young age.

多利在相对年轻的岁数患上骨关节炎，因此未老先衰，2003年不得不被实施安乐死。

People can also develop things called osteoarthritis, where you actually lose cartilage and you have more kind of bone on bone.

人们也可以患上叫做骨关节炎的病，你实际上失去了软骨，你的骨头上有更多种类的骨头。

This leads to the flood of enzymes and degradation seen in osteoarthritis, but is driven by different inflammatory proteins called cytokines.

也出现骨关节炎中产生大量酶和削弱关节的现象，但由不同的炎症蛋白引起，这种蛋白称为细胞因子。

The origins of osteoarthritis can often be traced to a patient’s early life, from any seemingly ordinary joint injury.

骨关节炎的起源通常可以追溯到患者的早年生活，源于任何看似普通的关节损伤。

Finally, management and treatment of osteoarthritis can involve non-pharmacological approaches, like losing weight or moderate exercise, as well as physical therapy.

最后，骨关节炎的治疗和处理常使用非药物疗法，如减肥或适当运动，以及物理疗法。

If Dolly was a typical example, it was possible that clones would die early of age-related diseases, like osteoarthritis.

如果多莉是一个典型的例子，克隆人有可能会早死于与年龄有关的疾病， 比如骨关节炎。

Higher rates of diabetes, hypertension, cardiovascular disease, even some cancers, osteoarthritis and a clear link to mental conditions such as depression.

糖尿病、高血压、心血管疾病，甚至某些癌症、骨关节炎的发病率更高，并且与抑郁症等精神疾病有着明显的联系。

A 2007 study looked at 200 people with knee pain from osteoarthritis, where the cartilage that cushions the bones is worn away.

2007 年的一项研究调查了 200 名因骨关节炎导致膝盖疼痛的人，其中缓冲骨骼的软骨被磨损。

To dig up this dirt on potatoes, the researchers actually piggybacked on another, totally unrelated study about knee osteoarthritis called the Osteoarthritis Initiative.

为了挖掘土豆上的污垢，研究人员实际上借助了另一项与膝骨关节炎完全无关的研究，称为骨关节炎倡议。

So there’s a chance that the nerve endings in the uncushioned bones of osteoarthritis patients could respond to pressure changes and ache, too.

因此，骨关节炎患者无衬垫骨骼中的神经末梢也有可能对压力变化和疼痛做出反应。

People with osteoarthritis often feel stiffness in the morning, which usually lasts less than 1 hour but comes back at the end of the day.

骨关节炎患者往往感到晨僵，晨僵时间往往不超过一小时，但在一天结束时又会发生。