Organ-on-a-chip

Lung-on-a-chip – The device consists of three hollow microchannels, and only the middle channel contains a horizontal porous membrane, coated on either side by either an endothelium or an epithelium tissue. The side channels are connected to a vacuum and can therefore simulate the stretching of the membrane. The contraction of the diaphragm triggers the intrapleural pressure to decrease, leading to an expansion of alveoli. This is the phenomenon essentially mimicked by this lung-on-a-chip.

Preparation of the Heart-on-a-chip substrate and contractility test samples – After applying a stimulating the contraction of the myocytes via the field electrodes, strips/teeth in the MTF start to curl. Researchers have developed a correlation between tissue stress and the radius of curvature of the MTF strips during the contractile cycle, validating the demonstrated chip as a heart-on-a-chip (in the realm of their respective needs).

Schematic of a nephron-on-a-chip device with cross-sections of 3 functional units – C – Connector; G – Glomerulus; T – Tubule; L – Henle's loop Black arrows: passive transportWhite arrows: cell-mediated active transport

Artery-on-a-chip and detail of inspection area – The green microchannel is used for loading the artery segment, and perfusion (delivery of nutrients to the luminal walls); the fixation channels in yellow are used to adjust the positioning of the organ in the inspection zone by applying sub-atmospheric pressures at each end; in red is the superfusion channel, used to deliver nutrients to the abluminal wall of the artery.

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.

单词	Organ on a chip
释义	Organ on a chip 原声例句 VOA常速英语_科技 They are used in the so called organ on a chip or OCP technology. 它们被用于所谓的芯片上的器官或OCP技术。《金融时报》 Podcast That's often called tissues on a chip or even organs on a chip. 这通常被称为芯片上的组织，甚至是芯片上的器官。英语百科 Organ-on-a-chip An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.
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Organ on a chip

Organ-on-a-chip