Organofluorine chemistry
![Segregation of alkyl and perfluoroalkyl substituents.[2]](/uploads/202501/31/Aliphatic_Fluorocarbon5342.jpg)
![Packing in a crystal pentafluorotolan (C6F5CCC6H5), illustrating the donor-acceptor interactions between the fluorinated and nonfluorinated rings.[3]](/uploads/202501/31/Aromatic_Fluorocarbon5342.jpg)


Organofluorine chemistry describes the chemistry of organofluorine compounds, organic compounds that contain the carbon–fluorine bond. Organofluorine compounds find diverse applications ranging from oil and water repellents to pharmaceuticals, refrigerants and reagents in catalysis. In addition to these applications, some organofluorine compounds are pollutants because of contributions to ozone depletion, global warming, bioaccumulation, and toxicity. The area of organofluorine chemistry often requires special techniques associated with the handling of fluorinating agents.