蛇根草属（学名：Ophiorrhiza）是茜草科下的一个属，为草本植物，很少为亚灌木。该属共有约150种，分布于热带亚洲。

Ophiorrhiza is a genus of flowering plants in the coffee (Rubiaceae) family. Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents. So many of Ophiorrhiza species are endemic to certain areas of western Ghats. Species include: